SAM-e 500mg 90 Capsules (S-Adenosyl Methionine)

Nothing else to say, apparently comparisons are not allowed

This product seems to be doing what is supposed to, but it sinks so bad. Also, try to eat soon after so you don't burp. It is not a pleasant experience.

Has maximum SamE per capsule and is competitively priced.

The work great but my goodness they smell rotten

I bought ClearFormulas SAM-e 500mg 90 Capsules (S-Adenosyl Methionine) for my brother and I since we were having similar depressive thoughts. They worked pretty well but I noticed I started to get a real bad sore throat and cough. I thought I was just getting sick, but when my brother who doesn't live anywhere near me, had the same symptoms, but worse; I thought maybe it was from these suppleents. So I quit taking them for awhile, and when I started back; I got sick again. My brother went to the hospital, and was put on 6 different medications. I feel terrible. Maybe we had an allergic reaction or maybe it's poor quality. I can not recommend them. I will not buy again. We through them out.

I have some inflammatory autoimmune health issues that hit me very suddenly at 29. Sam-e was one of the things I read about that your body stops making in high enough amounts starting at age 30. You have to take it regularly for a couple weeks before you see any results, always on an empty stomach if you can, I take mine first thing in the morning. These particular supplements have a weird smell but are otherwise fine, I’ve been taking these for about a week, but the regular Sam- e intake has helped my fatigue and arthritis so much I’ve been able to get out of bed on days I usually wouldn’t and I feel less pain overall, less stiffness. It also seemingly improves my mood, bc as you’d guess, being my age with debilitating arthritis can be a BUMMER. It helps, it doesn’t fix, my arthritis.

I wanted to do an authentic test so I stopped taking my other anti-inflammatory supplements (turmeric w/black pepper, Ceylon cinnamon, Berberine, Quercetin w/Bromelain, ginger) during a two (2) day trial. Additionally, I did not use any anti-inflammatory cream during these two days so I would not taint the test results. I work with my MD on using the above supplements for my condition and I recommend you work with yours for optimal results and safety.My CONDITION:-- Grade 3 OA (Osteoarthritis) of the knees-- Due to utilizing various supplements and creams I have mild to little symptoms most days but some days it can creep into moderate or worse symptomsPRO's:-- GMP certified facility-- FDA inspected facility-- Nominal fillers; less than typical-- Made in the USA-- Lab testedSAM-e BENEFITS:I researched respected medical websites and the main benefits with some research support were:-- OA (osteoarthritis)-- Depression, stress, anxiety-- Liver diseaseMy DOSE:DAY 1: I took one capsule before work and one capsule after lunch at work. Unfortunately, I tweaked one knee (no idea how) early in the day so there was additional pain that may have been meniscus related (pain was familiar from past injury). Regardless, it made it hard to gauge the relief. Within about 2 hours and 45 minutes of taking the 1st pill I already had a light arthritis burn building in the knees. Even the 2nd pill did not make it much easier to finish my work shift. I am on my feet either standing or walking about 50% or more of the day.DAY 2: Within 75 minutes of taking the 1st pill I had some light burning in the knees. After lunch I took the 2nd pill and it did help me get through my shift but it was not ideal. Again, tweaking my knee did not help here but I was definitely in a better place than day 1.Results = I will have to do another test for a longer duration when my knees are in a low to no pain state and see how they do as the day progresses.I will have to read more about the use of SAM-e since maybe two days is not enough for a real test. Sometimes supplements need to build in the system for a while. However, I have been able to rescue myself in the past taking turmeric or quercetin on bad days so this did leave me wondering if SAM-e may work for my occasional anxiety mood changes, but not as well for my arthritis. When my knee improves I will run another longer test to get a better idea.I do like this brand very much (have used other supplements by them) so hopefully this will work out in the future.

I've taken SAM-e for many years. I prefer to take this dosage--500mg-- once a day in the morning, before breakfast, because these loose capsules work better for me than the expensive time-release sort in the bubble packs. This brand seems to be working just as well as others I've tried, at a very attractive price point. The pills arrived nice and fresh, with no odor. I really like that this formulation has such a short list of ingredients and is free of all the major allergens. I can't take NSAIDs like ibuprofen because I've had ulcer problems, and SAM-e, which doesn't have any major side effects, doesn't cause such problems, so it's safe (and effective) for me.SAM-e helps with joint pain, and also helps to stabilize mood. It takes a while to notice results after starting to take SAM-e, and the improvements to joints and mood are subtle. I usually notice how helpful this stuff is when I run out and don't take it, and I can't move anymore because of my arthritis. Don't expect SAM-e to be a magic bullet, and don't take it "as needed" like a typical OTC painkiller (NSAID or alternative arthritis treatment/ pain reliever like MSM), because SAM-e needs to be taken daily to work well. Many formulations indicate that it's best to take before eating in the morning, so that's what I do. It's also important to store it in the refrigerator to keep it fresh, especially during the summer months, to prevent it from turning bad and smelling awful.In my personal experience, SAM-e is a far better mood stabilizer/antidepressant than commercial antidepressants, without the nasty side effects of prescription antidepressants (like massive weight gain). We gave SAM-e to my elderly father, who had advanced Parkinsons disease, and it really helped with (but didn't eliminate) his Parkinsons-related anger issues. SAM-e took the edge off, and that was a huge help.I'd recommend this product to anyone who has middle-aged achy joints, especially if you are stressed and find yourself snapping at those around you, since SAM-e can help with both mood and joints.